Intravenous Thrombolysis With Tenecteplase in Patients With Large Vessel Occlusions

Background and Purpose: Accumulating evidence from randomized controlled clinical trials suggests that tenecteplase may represent an effective treatment alternative to alteplase for acute ischemic stroke. In the present systematic review meta-analysis, we sought compare efficacy safety outcomes of intravenous administration stroke patients with large vessel occlusions (LVOs). Methods: We searched MEDLINE (Medical Literature Analysis Retrieval System Online) Scopus published providing confirmed LVO receiving thrombolysis either at different doses or a standard dose 0.9 mg/kg. The primary outcome was odds modified Rankin Scale score 0 2 3 months. Results: included 4 including total 433 patients. Patients had higher scores (odds ratio, 2.06 [95% CI, 1.15–3.69]), successful recanalization 3.05 1.73–5.40]), functional improvement defined as 1-point decrease across all grades (common 1.84 1.18–2.87]) months compared alteplase. There little no heterogeneity between results provided studies regarding aforementioned (I ≤20%). No difference in early neurological improvement, symptomatic intracranial hemorrhage, any rates 1 all-cause mortality detected Conclusions: Acute have significantly better